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18 November 2004
Oxford Diffraction Raises Expansion Funding.
Oxford Diffraction Limited secures expansion funding from existing investors TTP Ventures and a new investor Enterprise VCT plc (advised by Noble Fund Managers).

11 September 2004
Universität zu Lübeck to use an Oxford Diffraction Xcalibur PX Ultra system for Crystal Structural Studies of SARS Virus Proteins
The Institut für Biochemie at the Universität zu Lübeck, Germany, acquires an Xcalibur PX Ultra system to accelerate its structural biology programme focusing on the SARS virus

26 August 2004
Oxford Diffraction launches GEMINI – the complete service diffractometer – at ECM22
Oxford Diffraction Limited launched its new “Gemini” product at the European Crystallographic Meeting (ECM22) in Budapest this week. Gemini's defining features are co-mounted molybdenum and copper X-ray sources.

12 July 2004
R&D magazine have announced Oxford Diffraction's Xcalibur PX Ultra protein crystallography system as one of 2004's top 100 technologically significant new products and winner of the prestigious ‘R&D 100’ award.

24 June 2004
The Structural Genomics Consortium in Oxford becomes a protein crystallography reference site for Oxford Diffraction
The Structural Genomics Consortium (SGC) in Oxford, UK, has agreed to become the local reference site for Oxford Diffraction Limited for its novel Xcalibur PX Ultra protein crystallography product.

1 November 2003
Oxford Diffraction relocate to new premises
Due to ongoing rapid growth, Oxford Diffraction Limited has moved its head offices to a smart new site in the Oxfordshire region.

22 May 2003
Oxford Diffraction Launch Platinum Level US Reference Site for Crystallography at Virginia Tech
The current “Gold Level Reference Site” at Virginia Tech will now be promoted to the top “Platinum Level”, with the installation of a third Xcalibur, the innovative new Xcalibur PX Ultra.

15 September 2003
Johann Wolfgang Goethe-Universität, Frankfurt, becomes German reference site for Oxford Diffraction
The Institute of Minerology/Crystallography at the Johann Wolfgang Goethe-Universität, in Frankfurt am Main, become a Silver reference site for recently launched Xcalibur 3 single crystal X-ray diffractometer.

21 January 2003
Oxford Diffraction Limited Announce Collaboration with York Structural Biology Laboratory to Evaluate New Protein Crystallography X-ray Diffractometer
The York Structural Biology Laboratory (YSBL) and Oxford Diffraction Limited have today signed a heads of agreement to evaluate a new X-ray diffractometer, “Xcalibur PX Ultra”, intended for protein crystallography.

11 October 2002
Oxford Diffraction Launch Gold Level US Reference Site for Crystallography at Virginia Tech
Virginia Tech agrees Gold Reference Site with Oxford Diffraction as high profile US demonstration facility for single crystal diffractometers.

12 November 2002
Swiss Norwegian Beamline Purchase New Large Area CCD Detector for Six-Circle Synchrotron Diffractometer from Oxford Diffraction Limited
SNBL based at the ESRF synchrotron purchase the “ONYX” large-area CCD to mount on their six-circle diffractometer. The detector will be used for a variety of applications in single-crystal diffraction including protein crystallography.

10 September 2002
Oxford Diffraction launches Xcalibur PX – a compact and cost-effective macromolecular crystallography system
Oxford Diffraction Limited recently launched the “Xcalibur PX” single crystal diffractometer at the XIX IUCr meeting, held in Geneva in August. The Xcalibur PX system marks the entry of Oxford Diffraction Limited into protein crystallography.

7 March 2002
Crystal Cooling to <15 Kelvin : Oxford Diffraction's Helijet put through its paces at the ESRF, Europe's leading Synchrotron
ESRF demonstrate the Helijet's unique technical specifications that allow cooling of single crystals in X-ray diffraction to less than 15 Kelvin.

30 March 2001
Venture Funding for Oxfordshire spin-out to uncover the structure of molecules and proteins
Nearly two million pounds of new equity investment has been injected into an Oxfordshire company formed from a partnership including Oxford Instruments and TTP Ventures.
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11 September 2004

Universität zu Lübeck to use an Oxford Diffraction Xcalibur PX Ultra system for Crystal Structural Studies of SARS Virus Proteins

The Institut für Biochemie at the Universität zu Lübeck, Germany, acquires an Xcalibur PX Ultra system to accelerate its structural biology programme focusing on the SARS virus

The Institut für Biochemie at the Universität zu Lübeck has purchased Xcalibur PX Ultra to pursue its crystallographic studies of macromolecules from human pathogens of viral and bacterial origin involved in intracellular infections. Dr. Jeroen Mesters, Senior Research Assistant and Crystallography Team Leader, said of Xcalibur PX Ultra, “The perfect match to our in-house demands; an innovative, compact, low maintenance system, that goes clearly far beyond screening only!”. Rolf Hilgenfeld, director of the Institut für Biochemie, said that he was pleasantly surprised by the superb performance of the system. “I have relied on rotating-anode generators for 25 years and I would not have believed that a sealed-tube system can deliver such outstanding results”, he said. The Chief Executive of Oxford Diffraction Limited, Dr. Paul Loeffen, added “We are delighted that such a high profile institute doing such interesting work has decided to buy one of our Xcalibur PX Ultra systems. We eagerly look forward to seeing the results that will be generated”.

The Institut für Biochemie at the Universität zu Lübeck has played an important role in the emerging understanding of the SARS virus having solved the crystal structure of the first coronavirus main proteinase ( Science 300, 1763-1767 ), and subsequently entered a collaboration with a group in China on inhibitor complexes (PNAS 100, 13190-13195). The joint project on SARS is funded by the European Commission and by the Sino-German Center for the Promotion of Science.

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