18 November 2004
Oxford Diffraction Raises Expansion Funding.
11 September 2004
Universität zu Lübeck to use an Oxford Diffraction Xcalibur PX Ultra system for Crystal Structural Studies of SARS Virus Proteins
26 August 2004
Oxford Diffraction launches GEMINI – the complete service diffractometer – at ECM22
12 July 2004
24 June 2004
The Structural Genomics Consortium in Oxford becomes a protein crystallography reference site for Oxford Diffraction
1 November 2003
Oxford Diffraction relocate to new premises
22 May 2003
Oxford Diffraction Launch Platinum Level US Reference Site for Crystallography at Virginia Tech
15 September 2003
Johann Wolfgang Goethe-Universität, Frankfurt, becomes German reference site for Oxford Diffraction
21 January 2003
Oxford Diffraction Limited Announce Collaboration with York Structural Biology Laboratory to Evaluate New Protein Crystallography X-ray Diffractometer
11 October 2002
Oxford Diffraction Launch Gold Level US Reference Site for Crystallography at Virginia Tech
12 November 2002
Swiss Norwegian Beamline Purchase New Large Area CCD Detector for Six-Circle Synchrotron Diffractometer from Oxford Diffraction Limited
10 September 2002
Oxford Diffraction launches Xcalibur PX – a compact and cost-effective
macromolecular crystallography system
7 March 2002
Crystal Cooling to <15 Kelvin : Oxford Diffraction's Helijet put through its
paces at the ESRF, Europe's leading Synchrotron
30 March 2001
Venture Funding for Oxfordshire spin-out to uncover the structure of molecules and proteins
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7 March 2002
Crystal Cooling to <15 Kelvin : Oxford Diffraction's Helijet put through its paces at the ESRF, Europe's leading SynchrotronESRF demonstrate the Helijet's unique technical specifications that allow cooling of single crystals in X-ray diffraction to less than 15 Kelvin.The patented open-flow helium blower from Oxford Diffraction Limited has recently been assessed by the European Synchrotron Radiation Facility's (ESRF) Sample Environment Laboratory. Independent verification at the ESRF has demonstrated the Helijet's unique technical specifications that allow cooling of single crystals in X-ray diffraction to less than 15 Kelvin. Helijet has been developed, and is manufactured and distributed, by Oxford Diffraction Limited. Cooling to such low temperatures promises to increase data quality in X-ray crystallography by quenching thermal motion of the crystal lattice and constituent molecules, thereby improving the scattered diffraction signal, and by prolonging the life of vulnerable organic molecules (such as proteins) in X-ray beams by minimising radiation damage. Cooling to such low temperatures can also be used for phase-transition studies. Dr. Paul Loeffen, Managing Director of Oxford Diffraction Limited said "Helijet is the first truly commercial product of its type, allowing crystallographers to measure to temperatures as low as 15 Kelvin with a user-friendly and reliable product. We are seeing a strong uptake of this exciting new product as researchers become aware of its availability - several are installed on our Xcalibur range of diffractometers". The exhaustive tests at the ESRF demonstrated a base temperature of 11
Kelvin at the sample position. A root-mean-square temperature stability
of better than 0.5 Kelvin at 15K was also demonstrated over a period of
one hour. Dr. Heinz Graafsma, Scientist and Head of the Instrumentation
Support Group said: "Area detectors have completely changed the way
we do X-ray crystallography, and as an inevitable consequence crystal cooling
schemes had to be redesigned. It is clear that open flow systems are by
far the most practical to cool samples while using area detectors. The
availability of a system that goes down as low as 11 Kelvin opens up many
new exciting possibilities in different areas such as phase transitions
research, electron density studies and radiation damage control".
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